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KMID : 1151820170110020157
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Journal of the Korean Society of Radiology
2017 Volume.11 No. 2 p.157 ~ p.165
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Active Transport Characteristics of K+-Na+ Pumping System in Cell Membrane Model which Irradiated by High Energy X-ray
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Ko In-Ho
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Abstract
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The active transport characteristics of K + and Na + pumping system of cell membrane model which irradiated by high energy x-ray(linac 6MeV) was investigated. The cell membrane model used in this experiment was a Na + type sulfonated copolymerized membrane of styrene and divinylbenezene. The initial flux of the ion was increased with increase of both H + ion concentration. In this experiment range(pH 1.5-5, temperature 36.5 o C), the initial flux of K + which was not irradiated by radiation was found to be from 2.09x10 -4 to 1.32x10 -3 mole/cm 2 ·h and that of Na + from 7.09x10 -4 to 1.09x10 -3 mole/cm 2 ·h. the initial flux of K + which was irradiated by radiation was found to be from 21.0x10 -4 to 16.7x10 -3 mole/cm 2 ·h and that of Na + from 62.0x10 -4 to 20.6x10 -3 mole/cm 2 ·h. The ratio K + /Na + of membrane was about 1.10. And the driving force of pH of irradiated membrane was significantly increased about 9-20 times than membrane which was not irradiated. As active transport of K + and Na + of cell membrane model were abnormal, cell damages were appeared at cell.
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KEYWORD
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linac, high energy x-ray, K+, Na+, pH, sulfonated copolymerized membrane
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